Deadly Weight Loss, a POD World novella

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How to Take Nigella sativa Recommended dosage, active amounts, other details. Get access to the latest nutrition research By becoming an Examine. Human Effect Matrix. The Human Effect Matrix looks at human studies it excludes animal and in vitro studies to tell you what effects nigella sativa has on your body, and how strong these effects are.

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Grade Level of Evidence [show legend] Robust research conducted with repeated double-blind clinical trials Multiple studies where at least two are double-blind and placebo controlled Single double-blind study or multiple cohort studies Uncontrolled or observational studies only. Level of Evidence? The amount of high quality evidence. The more evidence, the more we can trust the results.

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The direction and size of the supplement's impact on each outcome. Some supplements can have an increasing effect, others have a decreasing effect, and others have no effect. Scientific research does not always agree.

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Blood Pressure. The reduction in blood pressure is only seen in hypertensives and very mild mmHg , likely not practically relevant at all. Reductions in LDL-C are mild at best and only occur in persons with impaired lipid profiles high cholesterol or dyslipidemia , but they do appear to occur with ingestion of the seed extract. Total Cholesterol. Decreases have been sporadically noted in persons with high cholesterol initially, the cholesterol reductions are mild at best and do not affect persons with normal cholesterol.

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One study has noted weight loss, but due to the reduction in appetite and no records of food intake the possibility of subjects losing weight due to eating less cannot be ruled out. Other studies have failed to find an influence of treatment.

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Mild increases have been reported in some cases, but for the most part nigella sativa does not influence HDL cholesterol in the active dosage range. Liver Enzymes. There may be a reducing effect in instances of liver damage this curative effect needs to be explored more , and there are no alterations in liver enzymes that would be indicative of liver damage. Supplementation of the seed appears to beneficially influence most symptoms associated with allergies and most causes of the allergies rhinitus, eczema, asthma, etc.

Subjective Well-Being. Although only based on one study, in men with central obesity and a wide variety of general health complaints supplementation has outright abolished all measured complaints such as loss of libido, high appetite, pain, and forgetfulness. The side-effect of 'high appetite' was effectively abolished in men with central obesity, which may underlie the observed weight loss; food intake was not reported in this study.

A slight improvement in cognition has been noted with supplementation of nigella seed extract in older persons. Nasal Congestion.

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Nasal congestion as a side-effect of allergic rhinitus is slightly reduced following the treatment of rhinitus with nigella sativa seeds. Processing Speed. Trail making test time in older adult men appears to be reduced modestly with daily supplementation of nigella seed extract. Pulmonary Function.

While the magnitude of benefit has not yet been compared to reference drugs, nigella sativa extracts appear to benefit lung function in both asthmatics and persons with otherwise damaged lung function; no studies in otherwise healthy persons. Seizure Frequency.

Seizure frequency in children with poorly controlled epilepsy is significantly reduced with a seed extract, and while it was quite notable in some children it was variable enough to also be quite modest in others. Needs more research to assess potency. Serum Albumin.

An increase in serum albumin has been noted, and the reason for this currently unknown. Symptoms of Rheumatoid Arthritis. Despite treating the viral load of hepatitis C, no significant changes in serum bilirubin exist. Blood Glucose. Although the best evidence to date shows no change in blood glucose, these studies were not structured to assess the influence on diabetics; in diabetics, there appears to be a significant reduction in glucose.

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C-Reactive Protein. The alterations in C-reactive protein failed to reach statistical significance, but are otherwise not very well explored. Food Intake. No significant alterations in food intake associated with ingestion of nigella sativa. Free Testosterone. No significant influence on circulating free testosterone concentrations in men with central obesity.

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Heart Rate. Processing Accuracy. No significant improvements in the accuracy of cognitive processing appears to occur with supplementation of nigella sativa seeds. No significant influence on the rate of proteinuria, suggesting no kidney damage associated with supplementation. Uric Acid. No statistically significant alterations in uric acid concentrations in serum.

Working Memory. Despite improvements in logical memory and 30 minute recall, digit span tests are not affected by supplementation of nigella sativa. Viral Load. A pilot study in hepatitis C noted that the viral load was reduced to Asthmatic symptoms appear to be reduced with supplementation of nigella sativa seeds, in part due to benefits to lung function and in part due to its anti-allergic properties. Potency has not been adequately assessed. A mild decrease in HbA1c has been noted in diabetics given the seeds as an adjuvant to standard therapy. Macrophage phagocytic activity and killing potential is increased following oral ingestion of the seed extract.

Red Blood Cell Count. A normalization of RBC count has been noted in the treatment of hepatitis C with the seed oil of nigella sativa. White Blood Cell Count. A normalization of WBC count has been noted in persons with hepatitis C being treated with the seed oil. No significant alterations in cortisol concentrations seen with supplementation of the seeds. Get access to the latest research By becoming an Examine.

Research Breakdown on Nigella sativa. Click on any below to expand the corresponding section. As such, it is a prime candidate for being a functional food product something that can be eaten in the diet for benefits exceeding normal nourishment.

The mineral content seems pretty variable The essential oil component 0. It is hypothesized that nigella sativa activates AMPK in a similar manner to berberine and Metformin, vicariously through causing mitochondrial uncoupling. It is not sure what causes this increased Akt phosphorylation although increased insulin signalling is likely a factor. May increase GABA concentrations itself. Thymoquinone appears to have anxiety reducing properties, and it is thought that this is secondary to a suppression of nitric oxide signalling in the brain preserving the functions of GABA signalling.

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The actual therapeutic potency of the seeds in hypertensive persons, while present, is of very small magnitude. However, it seems to work nicely with pharmaceutical options as it has been used in medicated diabetics and dyslipidemics without problem In hypertensive persons with no apparent alterations in lipid or glucose metabolism, supplementation of mg of a seed extract is ineffective in improving any biomarker for cholesterol or triglycerides.

This appears to be biologically relevant at an oral dose of the supplement that is commonly recommended to humans In persons with high cholesterol but no apparent problems with blood glucose, supplementation of 2g of the crushed seeds daily for four weeks failed to modify fasting blood glucose [76] and this failure has been noted over six weeks in the same cohort of persons [5] and over eight weeks in hypertensive that are not also diabetic.

Nigella sativa appears to be traditionally recommended as an anti-obesity agent [89] Supplementation of 2g of the seed extract daily over six weeks in overweight and hypercholesterolemic persons has failed to significantly reduce BMI and waist circumference [5] which has been noted elsewhere. This includes rheumatoid arthritis Supplementation of mg nigella sativa oil twice daily for one month in patients with rheumatoid arthritis noted that while placebo was unable to affect rheumatoid arthritis that the seed oil reduced the disease activity score DAS from 4. It seems moderately potent in vitro , and seems to be dependent on potassium channels.

However, a direct benficial influence on the lungs cannot be ruled out as it has shown benefit in persons without asthma. Nigella sativa appears to have anti-ulcer properties against the heliobacter pylori bacteria, with a potency somewhat comparable to a clarithromycin and amoxicillin combination therapy.